Assimilation of FY-4A GIIRS radiance observations in the forecast of Typhoon Bavi

We assimilated radiance observations from the Geostationary Interferometric Infrared Sounder (GIIRS) onboard the FengYun-4A geostationary satellite to evaluate their impact on the forecast of Typhoon Bavi using WRFDA. The temperature channels with high information content, representing 90% of the information content of all temperature channels, were selected for assimilation. All radiance observations above the cloud-top were assimilated by comparing the channel height to the cloud-top height coming from the product of the Advanced Geosynchronous Radiation Imager (AGRI). The assimilation of the GIIRS observations decreased the root-mean-square error of the temperature by 2% and improved the precipitation forecast. The rain band in southeast China was reproduced well, thus showing that infrared hyperspectral radiance observations have added value in improving the circulation around typhoons and, therefore, provide better forecasts. The increased relative humidity in the upper layer and stronger typhoon outflow were found to related to the intensify of typhoon in the analysis compared with the control experiment

Genetic and Epigenetic Alterations Underlie Oligodendroglia Susceptibility and White Matter Etiology in Psychiatric Disorders

Numerous genetic risk loci are found to associate with major neuropsychiatric disorders represented by schizophrenia. The pathogenic roles of genetic risk loci in psychiatric diseases are further complicated by the association with cell lineage- and/or developmental stage-specific epigenetic alterations. Besides aberrant assembly and malfunction of neuronal circuitry, an increasing volume of discoveries clearly demonstrate impairment of oligodendroglia and disruption of white matter integrity in psychiatric diseases. Nonetheless, whether and how genetic risk factors and epigenetic dysregulations for neuronal susceptibility may affect oligodendroglia is largely unknown. In this mini-review, we will discuss emerging evidence regarding the functional interplay between genetic risk loci and epigenetic factors, which may underlie compromised oligodendroglia and myelin development in neuropsychiatric disorders. Transcriptional and epigenetic factors are the major aspects affected in oligodendroglia. Moreover, multiple disease susceptibility genes are connected by epigenetically modulated transcriptional and post-transcriptional mechanisms. Oligodendroglia specific complex molecular orchestra may explain how distinct risk factors lead to the common clinical expression of white matter pathology of neuropsychiatric disorders

Two-stage Neural Network for ICASSP 2023 Speech Signal Improvement Challenge

In ICASSP 2023 speech signal improvement challenge, we developed a dual-stage neural model which improves speech signal quality induced by different distortions in a stage-wise divide-and-conquer fashion. Specifically, in the first stage, the speech improvement network focuses on recovering the missing components of the spectrum, while in the second stage, our model aims to further suppress noise, reverberation, and artifacts introduced by the first-stage model. Achieving 0.446 in the final score and 0.517 in the P.835 score, our system ranks 4th in the non-real-time track.Comment: Accepted by ICASSP 202

Progress of regional oceanography study associated with western boundary current in the South China Sea

Recent progress of physical oceanography in the South China Sea (SCS) associated with the western boundary current (WBC) and eddies is reviewed in this paper. It includes Argo observations of the WBC, eddy detection in the WBC based on satellite images, cross-continental shelf exchange in the WBC, eddy-current interaction, interannual variability of the WBC, air-sea interaction, the SCS throughflow (SCSTF), among others. The WBC in the SCS is strong, and its structure, variability and dynamic processes on seasonal and interannual time scales are yet to be fully understood. In this paper, we summarize progresses on the variability of the WBC, eddy-current interaction, air-sea interaction, and the SCSTF achieved in the past few years. Firstly, using the drifting buoy observations, we point out that the WBC becomes stronger and narrower after it reaches the central Vietnam coast. The pos-sible mechanisms influencing the ocean circulation in the northern SCS are discussed, and the dynamic mechanisms that induce the countercurrent in the region of northern branch of WBC in winter are also studied quantitatively using momentum balance. The geostropic component of the WBC was diagnosed using the ship observation along 18°N, and we found that the WBC changed significantly on interannual time scale. Secondly, using the ship observations, two anti-cyclonic eddies in the winter of 2003/2004 in the northern SCS, and three anti-cyclonic eddies in the summer of 2007 along 18°N were studied. The results show that the two anti-cyclonic eddies can propagate southwestward along the continental shelf at the speed of first Rossby wave (~0.1 m s1) in winter, and the interaction between the three anti-cyclonic eddies in summer and the WBC in the SCS is preliminarily revealed. Eddies on the continental shelf of northern SCS propagated southeastward with a maximum speed of 0.09 m s-1, and those to the east of Vietnam coast had the largest kinetic energy, both of which imply strong interaction between eddy activity and WBC in the SCS. Thirdly, strong intraseasonal variability (ISV) of sea surface temperature (SST) near the WBC regions was found, and the ISV signal of SST in winter weakens the ISV signal of latent heat flux by 20%. Fourthly, the long-term change of SCSTF volume transport and its connection with the ocean circulation in the Pacific were discussed

TRACE: A Comprehensive Benchmark for Continual Learning in Large Language Models

Aligned large language models (LLMs) demonstrate exceptional capabilities in task-solving, following instructions, and ensuring safety. However, the continual learning aspect of these aligned LLMs has been largely overlooked. Existing continual learning benchmarks lack sufficient challenge for leading aligned LLMs, owing to both their simplicity and the models' potential exposure during instruction tuning. In this paper, we introduce TRACE, a novel benchmark designed to evaluate continual learning in LLMs. TRACE consists of 8 distinct datasets spanning challenging tasks including domain-specific tasks, multilingual capabilities, code generation, and mathematical reasoning. All datasets are standardized into a unified format, allowing for effortless automatic evaluation of LLMs. Our experiments show that after training on TRACE, aligned LLMs exhibit significant declines in both general ability and instruction-following capabilities. For example, the accuracy of llama2-chat 13B on gsm8k dataset declined precipitously from 28.8\% to 2\% after training on our datasets. This highlights the challenge of finding a suitable tradeoff between achieving performance on specific tasks while preserving the original prowess of LLMs. Empirical findings suggest that tasks inherently equipped with reasoning paths contribute significantly to preserving certain capabilities of LLMs against potential declines. Motivated by this, we introduce the Reasoning-augmented Continual Learning (RCL) approach. RCL integrates task-specific cues with meta-rationales, effectively reducing catastrophic forgetting in LLMs while expediting convergence on novel tasks

A missense mutation in Pitx2 leads to early-onset glaucoma via NRF2-YAP1 axis.

Glaucoma is a leading cause of blindness, affecting 70 million people worldwide. Owing to the similarity in anatomy and physiology between human and mouse eyes and the ability to genetically manipulate mice, mouse models are an invaluable resource for studying mechanisms underlying disease phenotypes and for developing therapeutic strategies. Here, we report the discovery of a new mouse model of early-onset glaucoma that bears a transversion substitution c. G344T, which results in a missense mutation, p. R115L in PITX2. The mutation causes an elevation in intraocular pressure (IOP) and progressive death of retinal ganglion cells (RGC). These ocular phenotypes recapitulate features of pathologies observed in human glaucoma. Increased oxidative stress was evident in the inner retina. We demonstrate that the mutant PITX2 protein was not capable of binding to Nuclear factor-like 2 (NRF2), which regulates Pitx2 expression and nuclear localization, and to YAP1, which is necessary for co-initiation of transcription of downstream targets. PITX2-mediated transcription of several antioxidant genes were also impaired. Treatment with N-Acetyl-L-cysteine exerted a profound neuroprotective effect on glaucoma-associated neuropathies, presumably through inhibition of oxidative stress. Our study demonstrates that a disruption of PITX2 leads to glaucoma optic pathogenesis and provides a novel early-onset glaucoma model that will enable elucidation of mechanisms underlying the disease as well as to serve as a resource to test new therapeutic strategies

Binder-free highly conductive graphene laminate for low cost printed radio frequency applications

In this paper, we demonstrate realization of printable radio frequency identification (RFID) antenna by low temperature processing of graphene ink. The required ultra-low resistance is achieved by rolling compression of binder-free graphene laminate. With compression, the conductivity of graphene laminate is increased by more than 50 times compared to that of as-deposited one. Graphene laminate with conductivity of 4.3 x 10(4) S/m and sheet resistance of 3.8 Omega/sq (with thickness of 6 mu m) is presented. Moreover, the formation of graphene laminate from graphene ink reported here is simple and can be carried out in low temperature (100 degrees C), significantly reducing the fabrication costs. A dipole antenna based on the highly conductive graphene laminate is further patterned and printed on a normal paper to investigate its RF properties. The performance of the graphene laminate antenna is experimentally measured. The measurement results reveal that graphene laminate antenna can provide practically acceptable return loss, gain, bandwidth, and radiation patterns, making it ideal for low cost printed RF applications, such as RFID tags and wearable wireless sensor networks.close1

A Comparison of Information Content at Microwave to Millimeter Wave Bands for Atmospheric Sounding

The brightness temperatures and their Jacobians with respect to atmospheric temperature and humidity at the microwave to millimeter wave spectral bands from 23 GHz to 424 GHz are simulated with the ECMWF IFS-137 profiles as inputs to the Advanced Radiative transfer Modeling System (ARMS). The information content of temperature and humidity is then calculated individually through the Shannon entropy which is contributed by a-priori background information and observations. For a typical set of measurement uncertainties, a high information content for atmospheric temperature is mainly obtained from V band near 50–70 GHz, whereas that for water vapor comes from G band near 183 GHz and Y1 band near 380 GHz. The channels within the G band have a large temperature information content mainly for lower and middle layers of troposphere and the Y1 band has a relatively large humidity information content for the entire troposphere. A large measurement uncertainty can significantly reduce the information content of each band. Thus, to make a best use of the data from each band, it is important to reduce the instrument calibration noise and increase the accuracy in forward radiative transfer simulation

A Comparison of Information Content at Microwave to Millimeter Wave Bands for Atmospheric Sounding

The brightness temperatures and their Jacobians with respect to atmospheric temperature and humidity at the microwave to millimeter wave spectral bands from 23 GHz to 424 GHz are simulated with the ECMWF IFS-137 profiles as inputs to the Advanced Radiative transfer Modeling System (ARMS). The information content of temperature and humidity is then calculated individually through the Shannon entropy which is contributed by a-priori background information and observations. For a typical set of measurement uncertainties, a high information content for atmospheric temperature is mainly obtained from V band near 50–70 GHz, whereas that for water vapor comes from G band near 183 GHz and Y1 band near 380 GHz. The channels within the G band have a large temperature information content mainly for lower and middle layers of troposphere and the Y1 band has a relatively large humidity information content for the entire troposphere. A large measurement uncertainty can significantly reduce the information content of each band. Thus, to make a best use of the data from each band, it is important to reduce the instrument calibration noise and increase the accuracy in forward radiative transfer simulation

Assessment of the Hyperspectral Infrared Atmospheric Sounder (HIRAS)

The hyperspectral infrared atmospheric sounder (HIRAS), the first Chinese hyperspectral infrared instrument, was launched in 2017 on board the fourth polar orbiter of the Feng Yun 3 series, FY-3D. The instrument is a Fourier transform spectrometer with 2275 channels covering three spectral bands (650–1136, 1210–1750, and 2155–2550 cm−1) with 0.625 cm−1 spectral resolution. The first data quality assessment of HIRAS observations at full and normal spectral resolutions is presented. Comparisons with short-range forecasts from the Met Office numerical weather prediction (NWP) global system have revealed biases (standard deviation) generally less than 2.6 K (2 K) in the spectral regions mostly unaffected by trace gases where the confidence in the NWP model is largest. Of particular concern, HIRAS detector 3 seems to suffer from sunlight contamination of its calibration towards the end of the descending node. This, together with an obstruction of the detector field of view by an element of the platform, results in accentuated bias and noise in the observations from this detector. At normal spectral resolution, a background departure double difference analysis has been conducted between HIRAS and the NOAA-20 crosstrack infrared sounder (CrIS). The results show that HIRAS and CrIS are in good agreement with a mean difference across the three bands of −0.05 K (±0.26 K at 1σ) and 75.2% of the channels within CrIS radiometric uncertainty, noting though that HIRAS is noisier than CrIS with, on average, a standard deviation 0.34 K larger